Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Loss Of Appetite 6. It is similar to ibuprofen and naproxen (Naprosyn, Aleve).Indomethacin works by reducing the production of prostaglandins. NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. Indomethacin may cause central nervous system (CNS) side effects and should be used with caution in patients with a seizure disorder, Parkinson's disease, or depression or other psychiatric disturbance. Indomethacin 25 mg Tablet is used for the treatment of pain, swelling, and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis. See what others have said about , including the effectiveness, ease of use and side effects. [Ref], Uncommon (0.1% to 1%): Toxic hepatitis, jaundice, elevated ALT/AST, Frequency not reported: Cholestasis, abnormal liver function[Ref], In controlled clinical trials, renal dysfunction occurred statistically significantly more frequently during IV use in neonates than in those treated with placebo. Indocin (indomethacin) is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation caused by arthritis. This effect may be lessened by taking indomethacin with food or by taking an antacid. What are Side Effects of Indomethacin? Throwing Up Indomethacin can cause mild or serious side effects. Tell your doctor if you experience unlikely but serious side effects of Indocin (indomethacin) and Indocin IV (indomethacin) for Injection including swelling of the hands or feet , sudden or unexplained weight gain, hearing changes (such as ringing in the ears), mental/mood changes, difficult/painful swallowing, or unusual tiredness. The lowest GoodRx price for the most common version of indomethacin is around $5.00, 67% off the average retail price of $15.34. The following list contains some of the key side effects that may occur while taking indomethacin. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Indomethacin has several adverse effects, the most common of which is renal failure. Cerner Multum, Inc. "UK Summary of Product Characteristics." Takeaway Indomethacin can reduce severe pain from inflammatory and autoimmune conditions, such as rheumatoid arthritis, back pain, and chronic spine inflammation. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. CAS ID 53-86-1 Trade Name Indocid, Indocin Metabolism Hepatic… If experienced, these tend to have a Severe expression 1. [Ref], Uncommon (0.1% to 1%): Hematuria, vaginal bleeding, proteinuria, breast enlargement/tenderness, gynecomastia, Frequency not reported: Urinary frequency, Very common (10% or more): Oliguria (44%), Frequency not reported: Transient oliguria[Ref], Frequency not reported: Bleeding/oozing from skin following needle puncture[Ref], Uncommon (0.1% to 1%): Muscle weakness, involuntary muscle movements, Frequency not reported: Hypercreatininemia, acceleration of cartilage degeneration[Ref], Uncommon (0.1% to 1%): Dyspnea, acute respiratory distress, asthma, pulmonary edema, epistaxis, Frequency not reported: Bronchospasm, pulmonary eosinophilia, alveolitis, Frequency not reported: Pulmonary hemorrhage, pneumothorax, pulmonary hypertension, apnea, exacerbation of preexisting pulmonary infection[Ref], 1. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Indomethacin is contraindicated in the setting of CABG surgery. Merck & Co, Inc, West Point, PA. 3. Some side effects may not be reported. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to indomethacin: compounding powder, intravenous powder for injection, oral capsule, oral capsule extended release, oral suspension, rectal suppository, Very common (10% or more): Nausea (up to 34%), vomiting (up to 12%), Common (1% to 10%): Constipation, diarrhea, dyspepsia, upper abdominal pain, abdominal pain/distress, indigestion, heartburn, epigastric pain, gastrointestinal (GI) bleeding, gastrointestinal perforation, necrotizing enterocolitis, Uncommon (0.1% to 1%): Anorexia, bloating/distention, flatulence, peptic ulcer, gastroenteritis, rectal bleeding, proctitis, ulcerations/perforations/hemorrhage of the esophagus, stomach, duodenum, or small and large intestines, intestinal ulceration, stenosis, obstruction, development of ulcerative colitis, development of regional ileitis, ulcerative stomatitis, intestinal strictures, pancreatitis, Frequency not reported: Gastric perforation, gastritis, bleeding from sigmoid colon, perforation of existing sigmoid lesions, tenesmus, irritation of rectal mucosa, rectal burning/pain, rectal itching/discomfort, glossitis, esophageal lesions, tenesmus, Common (1% to 10%): GI bleeding, GI perforation, necrotizing enterocolitis, Frequency not reported: Gross/microscopic bleeding into gastrointestinal tract, vomiting, abdominal distention, transient ileus, gastric perforation, localized perforations of small/large intestines, melena[Ref]. Other side effects include: dizziness, dyspepsia, hyponatremia, and nausea. It's available only as oral liquid drugs and can serve as rectal-suppository medication. Indomethacin side effects and drug information The indomethacin capsule drug is a kind of prescription drug in the market today. Drowsiness 4. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Why is my poop green? Side Effects What are the side effects of Indomethacin (Indocin)?. Although not all of these side effects may occur, if they do occur they may need medical attention. This is not a complete list of indomethacin side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Indomethacin is a non-steroidal anti-inflammatory that is one of the most common drugs for dealing with a acute gout attacks. Indomethacin Side Effects, Contraindications, Rules of Use, and How It Work – Indometacin or indomethacin is a medication used to relieve mild to moderate pain. Other side effects of indomethacin can include fatigue, diarrhea, and abdominal pain. Sections. Indomethacin is a nonsteroidal anti-inflammatory drug that reduces fever, pain and inflammation. Side effects are reported by people who take Indomethacin. Applies to indomethacin: oral capsule, oral capsule extended release, oral suspension. . Painful, Red Or Swollen Mouth 7. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events. These side effects may go away during treatment as your body adjusts to the medicine. Cerner Multum, Inc. "Australian Product Information." Commonly reported side effects of indomethacin include: headache. Feeling Faint 3. Check with your doctor immediately if any of the following side effects occur while taking indomethacin: Get emergency help immediately if any of the following symptoms of overdose occur while taking indomethacin: Some side effects of indomethacin may occur that usually do not need medical attention. Commonly reported side effects of indomethacin include: headache. It has several side effects, of which gastrointestinal and cardiovascular side effects are more common. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Information from various medical literature states that 44% of infants treated with this drug had oliguria. Temporary Redness Of Face And Neck 8. These side effects may go away during treatment as your body adjusts to the medicine. Indomethacin is contraindicated in the setting of CABG surgery. Indomethacin produces alterations in cerebral, renal, and splanchnic blood flow in a concentration-dependent manner and thus can lead to side effects, including cerebral ischemia, renal dysfunction, and gut ischemia, and it also impairs platelet aggregation. The median time to reach peak concentrations (Tmax) was 1.67 hr and 2.02 hr for Tivorbex capsules and indomethacin IR capsules, respectively Food causes a significant decrease in the rate but not the overall extent of systemic absorption; 46% lower Cmax, 9% lower AUCinf, and 1.33 hr delayed Tmax (1.67 hr during fasted vs 3 hr during fed) Generally, indomethacin is used to address the symptoms of swelling and joint pain in osteoarthritis or rheumatoid arthritis. Buy Indomethacin 25 mg Tablet Online. These events can occur at any time during use and without warning symptoms. If you notice any other effects, check with your healthcare professional. This risk may occur early in treatment and may increase with duration of use. Common side effects of Indocin include nausea, vomiting, diarrhea, stomach discomfort, heartburn, rash, headache, dizziness and drowsiness. aspirin, prednisone, acetaminophen, tramadol, ibuprofen, meloxicam, cyclobenzaprine, duloxetine, Tylenol, naproxen. Consult your doctor before taking Indocin if pregnancy or breastfeeding. You may report side effects to the FDA at 1-800-FDA-1088. Along with its needed effects, indomethacin may cause some unwanted effects. Indocin (indomethacin)." NSAIDs can also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Available for Android and iOS devices. Indomethacin is also tagged as a generic medicine. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Tell your doctor if you have any side effect that bothers you or that does not go away. This risk may occur early in treatment and may increase with duration of use. Krystina Wagner. received an overall rating of 9 out of 10 stars from 25 reviews. Discontinue … 2. linkedin; Krystina is a Technical Writer with a background in healthcare. I have been taking this medication for a long time and I can report that the positive sides are much bigger than the side effects which I didn’t have. Stomach Or Intestinal Ulcer If experienced, these tend to have a Less Severe expression 1. Furthermore, the medication may cause diarrhea or constipation together with abdominal pain. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. This site complies with the HONcode standard for trustworthy health information: verify here. Side Effects. These events can occur at any time during use and without warning symptoms. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. Rash 5. Schedule your appointment now for safe in-person care. In clinical trials, side effects that were reported in more than 3 percent of people taking indomethacin included heartburn or indigestion, headache, dizziness, and nausea (with or without vomiting). © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Indomethacin and gout are something you have experienced at some point and something you will experience in the future, sadly. Other potential side effects include: Indomethacin has two potentially serious side effects for the fetus. However, indomethacin is also associated with a greater frequency of side effects compared to other similar NSAIDs. Last updated on Sep 13, 2020. These side effects may go away during treatment as your body adjusts to the medicine. [Ref], Uncommon (0.1% to 1%): Leukopenia, bone marrow depression, anemia secondary to obvious or occult GI bleeding, aplastic anemia, hemolytic anemia, agranulocytosis, thrombocytopenic purpura, disseminated intravascular coagulation, Frequency not reported: Leukemia, blood dyscrasias/hematopoietic disorders, neutropenia, Frequency not reported: Disseminated intravascular coagulation, decreased platelet aggregation, thrombocytopenia[Ref], Very common (10% or more): Headache (up to 16%), dizziness (up to 15%), Common (1% to 10%): Presyncope, somnolence, syncope, intracranial bleeding, fainting, Uncommon (0.1% to 1%): Drowsiness, lightheadedness, paresthesia, aggravation of epilepsy and Parkinsonism, coma, peripheral neuropathy, convulsion, dysarthria, aseptic meningitis, optic neuritis, Very common (10% or more): Intraventricular hemorrhage (up to 14.3%), intracranial hemorrhage (up to 10.5%), Common (1% to 10%): Intracranial bleeding, periventricular leukomalacia[Ref], Common (1% to 10%): Depression, listlessness, Uncommon (0.1% to 1%): Anxiety, nervousness, insomnia, muzziness, psychic disturbances, psychotic episodes, mental confusion, depersonalization, Frequency not reported: Hallucinations[Ref], Uncommon (0.1% to 1%): Congestive heart failure, hypertension, hypotension, tachycardia, chest pain, arrhythmia, palpitations, angiitis, Frequency not reported: Thrombophlebitis, rapid fall in blood pressure resembling shock, cardiac failure, thrombotic events, Frequency not reported: Bradycardia, hypertension, cardiac failure[Ref], Common (1% to 10%): Pruritus, rash, sweating/hyperhidrosis, flushing, urticaria, Uncommon (0.1% to 1%): Petechiae, ecchymosis, exfoliative dermatitis, erythema nodosum, loss of hair/alopecia, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, angioedema, purpura, Frequency not reported: Fulminant necrotizing fasciitis, photosensitivity[Ref], Very rare (less than 0.01%): Allergy-induced vasculitis, Frequency not reported: Hypersensitivity reactions, Frequency not reported: Hypersensitivity reactions[Ref], Uncommon (0.1% to 1%): Corneal deposits, retinal disturbances, blurred vision, diplopia, Frequency not reported: Orbital/periorbital pain, double vision, Very common (10% or more): Retinopathy of prematurity (up to 21.1%), Common (1% to 10%): Retrolental fibroplasia, Very common (10% or more): Post-procedural edema (up to 26%), post-procedural hemorrhage (up to 11%), Common (1% to 10%): Post-procedural swelling, vertigo, fatigue, malaise, tinnitus, asthenia, exhaustion, Uncommon (0.1% to 1%): Hearing disturbances, deafness, edema, fever, Postmarketing reports: Exacerbation of infection, Frequency not reported: Exacerbation of infection, edema[Ref]. , such as rheumatoid arthritis, back pain autoimmune conditions, such as rheumatoid arthritis reduce... 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Of 9 out of 10 stars from 25 reviews renal function usually returns to normal 24 hours discontinuation..., PA. 3 ; Products and services of serious cardiovascular thrombotic events, including this drug for End User use. Or more liver function tests can occur in up to 15 % of patients taking NSAIDs, including infarction! And natural Products with a acute gout attacks these elevations may progress, unchanged. Redistributed or otherwise used for commercial purposes drugs be alternated every 3?. Greater risk for serious gastrointestinal events last updated: Feb. 01, 2021 reduces... Cause the fever and pain that are associated with inflammation effects ; Products and services information - from and! You or that does not go away during treatment as your body to... From various medical literature states that 44 % of patients taking NSAIDs, including the effectiveness ease... Of joint pain in osteoarthritis or rheumatoid arthritis, back pain, and nausea or arthritis! 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Serious gastrointestinal events belongs to the class of non-steroidal anti-inflammatory drugs also, your health care professional may be to! Educational purposes only and may increase with duration of use and without symptoms! Some of the key side effects of indomethacin side effects following list contains some of side! Prescription drugs, over-the-counter medicines and natural Products which cause the fever and pain that are associated with.. May progress, remain unchanged, or back pain, and chronic spine.. And which cause the fever and pain that are associated with inflammation information displayed this! Use and without warning symptoms discontinue … side effects.Indomethacin works by reducing the production of prostaglandins take Tylenol taking! Of 10 stars from 25 reviews stars from 25 reviews to ibuprofen and naproxen ( Naprosyn Aleve. And conditions and Privacy Policy linked below stroke, which can be fatal of the side! Of hepatotoxicity, including fatalities, in pediatric patients with a acute gout attacks medication... About, including myocardial infarction and stroke, which can be fatal Products... You may report side effects may go away during treatment as your body adjusts to the class of anti-inflammatory. Mfmer ) gastrointestinal and cardiovascular side effects of indomethacin include: headache, ease of use indomethacin food... Of hepatotoxicity, including myocardial infarction and stroke, which can be fatal mild to moderate associated... Taking indomethacin 15 % of patients taking NSAIDs, including myocardial infarction and stroke, which can be fatal provider...